Cleft, usually due to incomplete embryologic development in utero. An iris coloboma is the most common eye coloboma; the pupil will often look like a keyhole or upside-down pear. Colobomas can also affect other eye structures, such as the eyelid, retina and optic nerve; only iris and eyelid colobomas are visible with the naked eye. Additional symptoms such as poor vision may occur, but are not readily apparent from a parent's perspective. See also: Patau syndrome.